PREDICTING FACTORS OF CLINICAL OUTCOMES IN TRAUMATIZED ADULTS AND OLDER ADULTS - Peeref (2024)

Review Geriatrics & Gerontology

Application of machine learning approaches in predicting clinical outcomes in older adults - a systematic review and meta-analysis

Robert T. Olender, Sandipan Roy, Prasad S. Nishtala

Summary: This study evaluated the performance of machine learning models in predicting clinical outcomes in older adults through systematic review and meta-analysis. The results showed that machine learning models have good discriminatory power in predicting mortality, but further large-scale validation studies are needed.

Article Nutrition & Dietetics

Predicting visceral adipose tissue in older adults: A pilot clinical study

Simone Perna, Alessandro Faragli, Daniele Spadaccini, Gabriella Peroni, Clara Gasparri, Mariam Ahmed Al-Mannai, Pietro Mariano Casali, Edoardo La Porta, Sebastian Kelle, Alessio Alogna, Mariangela Rondanelli

Summary: The independent and combined use of bioimpedance analysis, anthropometric measures, and biochemical markers can accurately predict visceral adipose tissue in the older adults' population. Weight, triglycerides, and height are key factors in predicting visceral adipose tissue.

Article Cardiac & Cardiovascular Systems

Health Status and Clinical Outcomes in Older Adults With Chronic Coronary Disease

Dan D. Nguyen, John A. Spertus, Karen P. Alexander, Jonathan D. Newman, John A. Dodson, Philip G. Jones, Susanna R. Stevens, Sean M. O'Brien, Reto Gamma, Gian P. Perna, Pallav Garg, Joao V. Vitola, Benjamin J. W. Chow, Andras Vertes, Harvey D. White, Paola E. P. Smanio, Roxy Senior, Claes Held, Jianghao Li, William E. Boden, Daniel B. Mark, Harmony R. Reynolds, Sripal Bangalore, Paul S. Chan, Gregg W. Stone, Suzanne V. Arnold, David J. Maron, Judith S. Hochman, ISCHEMIA Res Grp

Summary: This study examined the impact of age on health status and clinical outcomes with invasive vs conservative management. It was found that older patients had less improvement in angina frequency but more improvement in angina-related health status compared to younger patients. Invasive management did not improve clinical outcomes in both older and younger patients.

Article Medicine, General & Internal

Subtypes of Premorbid Metabolic Syndrome and Associated Clinical Outcomes in Older Adults

Chu-Sheng Lin, Wei-Ju Lee, Shih-Yi Lin, Hui-Ping Lin, Ran-Chou Chen, Chi-Hung Lin, Liang-Kung Chen

Summary: This study aimed to explore the subtypes of metabolic syndrome and their associations with new onset of diabetes, cardiovascular disease, and major adverse cardiovascular events (MACE). The findings suggest that the risks vary among different subtypes of metabolic syndrome.

Article Geriatrics & Gerontology

Race,APOL1Risk Variants, and Clinical Outcomes among Older Adults: TheARICStudy

Teresa K. Chen, Josef Coresh, Natalie Daya, Shoshana H. Ballew, Adrienne Tin, Deidra C. Crews, Morgan E. Grams

Summary: Among older Black adults, APOL1 high-risk genotypes were associated with lower kidney function and therefore higher risk of ESRD. Racial disparities in incident kidney disease persisted in older age and were not fully explained by APOL1.

Article Medicine, General & Internal

Frailty assessment, hip fracture and long-term clinical outcomes in older adults

Monica Pizzonia, Chiara Giannotti, Luca Carmisciano, Alessio Signori, Gianmarco Rosa, Federico Santolini, Irene Caffa, Fabrizio Montecucco, Alessio Nencioni, Fiammetta Monacelli

Summary: The study validated the modified 19-item Frailty Index (mFI-19) compared to the gold standard comprehensive geriatric assessment (CGA), finding similar predictive accuracies in long-term mortality. This research provides a methodologically robust frailty screening assessment for older adults with hip fractures.

Article Geriatrics & Gerontology

Risk Factors for Nonresilient Outcomes in Older Adults After Total Knee Replacement

Thomas Laskow, Jiafeng Zhu, Brian Buta, Julius Oni, Frederick Sieber, Karen Bandeen-Roche, Jeremy Walston, Patricia D. Franklin, Ravi Varadhan

Summary: This study aims to define a simple measure of physical resilience and identify risk factors for nonresilient outcomes in patients who undergo total knee replacement. By analyzing the associated factors, it may aid in clinical risk stratification, further investigate the causes, and ultimately assist in designing interventions to enhance physical resilience.

Article Immunology

Traumatized triad of complementopathy, endotheliopathy, and coagulopathy - Impact on clinical outcomes in severe polytrauma patients

Zhangsheng Yang, Tuan D. Le, Milomir O. Simovic, Bin Liu, Tamara L. Fraker, Tomas S. Cancio, Andrew P. Cap, Charles E. Wade, Jurandir J. DalleLucca, Yansong Li

Summary: The study found that severely injured patients had significantly higher levels of complement activation products, endothelial damage markers, and fibrinolytic markers in blood plasma compared to less severely injured patients. Complement activation was correlated with endothelial damage and hypocoagulopathy.

Article Genetics & Heredity

Application of RNA processing factors for predicting clinical outcomes in colon cancer

Liujin Hou, Fan Huang, Guanghou Chen, Jian Qiu, Yuyao Liu, Hongchuan Zhao, Zhengguang Wang

Summary: This study performs systematic bioinformatics analysis of prognostic-associated RNA processing factor genes in colon cancer and proposes 13 RNA processing factor genes as a prognostic factor for colon cancer patients. The risk score based on the gene expression profile can independently predict the clinical outcome. The interaction of these genes with the immune system during colon carcinogenesis provides new ideas for the molecular mechanisms and targeted therapies for colon cancer.

Article Health Care Sciences & Services

Predictive analytics and tailored interventions improve clinical outcomes in older adults: a randomized controlled trial

Sara Bersche Golas, Mariana Nikolova-Simons, Ramya Palacholla, Jorn op den Buijs, Gary Garberg, Allison Orenstein, Joseph Kvedar

Summary: This study investigated the use of predictive analytics combined with tailored nurse-driven interventions to improve clinical outcomes in older adults. The results showed significant reductions in readmission rates and EMS encounters in the Intervention group compared to the Control group, suggesting the potential benefits of this approach in population health management.

Article Geriatrics & Gerontology

Urine creatinine concentration and clinical outcomes in older adults: The Cardiovascular Health Study

Joshua Barzilay, Petra Buzkova, Michael G. Shlipak, Mary F. Lyles, Nisha Bansal, Pranav S. Garimella, Joachim H. Ix, Jorge R. Kizer, Elsa S. Strotmeyer, Luc Djousse, Mary L. Biggs, David Siscovick, Kenneth J. Mukamal

Summary: The study showed that spot urine creatinine concentration is positively associated with muscle mass and health outcomes in older adults.

Article Geriatrics & Gerontology

Clinical outcomes of older adults listed for heart transplantation in the United States

Abhishek Jaiswal, Naga Vaishnavi Gadela, David Baran, Kathir Balakumaran, Andrew Scatola, Joseph Radojevic, Jason Gluck, Sabeena Arora, Jonathan Hammond, Ayyaz Ali, Douglas L. Jennings, William L. Baker

Summary: The study found that post-transplant survival up to 5 years among patients aged >= 70 years was similar to that of younger recipients, although older recipients received hearts from higher risk donors. Therefore, chronological age alone should not constitute a contraindication for heart transplantation, although careful patient selection criteria should be applied.

Article Geriatrics & Gerontology

Clinical presentation of COVID-19 and association with outcomes among hospitalized older adults

Ugochi Ohuabunwa, Phebe Afolabi, Daniel Tom-Aba, Shelly-Ann Fluker

Summary: This study aimed to characterize the symptomatology of COVID-19 and examine the association of symptoms with in-hospital mortality and respiratory failure in older, predominantly African American adults. The study found that older adults infected with SARS-CoV-2 may present with a range of symptoms including typical, atypical, and geriatric syndromes. Early testing for COVID-19 should be considered in hospitalized older adults.

Review Geriatrics & Gerontology

Clinical features and outcomes of COVID-19 in older adults: a systematic review and meta-analysis

Sunny Singhal, Pramod Kumar, Sumitabh Singh, Srishti Saha, Aparajit Ballav Dey

Summary: The study shows that approximately half of older patients with COVID-19 have severe infection, one in five are critically ill, and one in ten die. The most common comorbidities are hypertension, diabetes mellitus, and cardiovascular disease, while common symptoms include fever, cough, and dyspnea. The majority of patients require oxygen support, and 21% require mechanical ventilation.

Article Multidisciplinary Sciences

Clinical and microbiological factors predicting outcomes of nonfermenting gram-negative bacilli peritonitis in peritoneal dialysis

Ana Claudia Moro Lima dos Santos, Rodrigo Tavanelli Hernandes, Augusto Cezar Montelli, Aydir Cecilia Marinho Monteiro, Thais Alves Barbosa, Carlos Henrique Camargo, Adriano Martison Ferreira, Alessandro Lia Mondelli, Maria de Lourdes Ribeiro de Souza da Cunha, Pasqual Barretti

Summary: This study reviewed 62 episodes of peritonitis caused by NF-GNB, finding a high proportion of biofilm producer lineages and a significant association between preexisting exit-site infection and nonresolution. Despite higher in vitro susceptibility of Pseudomonas compared to other NF-GNB, there was a similar low resolution rate among the episodes, suggesting that bacterial virulence factors such as biofilms may worsen the outcome.

Article Health Care Sciences & Services

Tackling Ambulatory Safety Risks Through Patient Engagement: What 10,000 Patients and Families Say About Safety-Related Knowledge, Behaviors, and Attitudes After Reading Visit Notes

Sigall K. Bell, Patricia Folcarelli, Alan Fossa, Macda Gerard, Marvin Harper, Suzanne Leveille, Caroline Moore, Kenneth E. Sands, Barbara Sarnoff Lee, Jan Walker, Fabienne Bourgeois

Summary: The study found that patients and parents believe that reading clinical notes helps them understand and follow through on tests and referrals. The majority of participants reported improvements in trust in the provider, activation, patient-provider goal alignment, and teamwork after reading the notes.

Article Clinical Neurology

Chronic Musculoskeletal Pain and Foot Reaction Time in Older Adults

Yurun Cai, Suzanne G. Leveille, Jeffrey M. Hausdorff, Jonathan F. Bean, Brad Manor, Robert R. McLean, Tongjian You

Summary: This study found an association between chronic pain and slower foot reaction time in older adults, with pain severity and knee pain being linked to slower foot reaction time. Cognitive measures had little impact on this relationship, and it was only observed in participants with lower education levels. These findings suggest that chronic pain may increase fall risk in older adults by affecting foot reaction time.

Article Public, Environmental & Occupational Health

Care partners reading patients' visit notes via patient portals: Characteristics and perceptions

Sara L. Jackson, Hannah Shucard, Joshua M. Liao, Sigall K. Bell, Alan Fossa, Thomas H. Payne, Lisa M. Reisch, Andrea C. Radick, Catherine M. DesRoches, Patricia Fitzgerald, Suzanne Leveille, Jan Walker, Joann G. Elmore

Summary: This study aimed to understand the experiences of care partners accessing patient information through electronic portals. The majority of care partners, who were often family members, considered access to electronic visit notes very important for promoting positive health behaviors. They suggested improvements to the portal design, such as separate logins for care partners and avoiding judgmental language in the notes.

Article Geriatrics & Gerontology

Chronic pain and circ*mstances of falls in community-living older adults: an exploratory study

Yurun Cai, Suzanne G. Leveille, Ling Shi, Ping Chen, Tongjian You

Summary: Chronic pain in older adults is associated with specific circ*mstances of falls, such as indoor falls in living or dining rooms, and falls due to health problems or feeling dizzy. However, fallers with moderate-to-severe pain are less likely to fall while going down stairs or due to a slip or trip.

Article Health Care Sciences & Services

Patients Contributing to Visit Notes: Mixed Methods Evaluation of OurNotes

Jan Walker, Suzanne Leveille, Gila Kriegel, Chen-Tan Lin, Stephen K. Liu, Thomas H. Payne, Kendall Harcourt, Zhiyong Dong, Patricia Fitzgerald, Matthew Germak, Lawrence Markson, Sara L. Jackson, Hannah Shucard, Joann G. Elmore, Tom Delbanco

Summary: OurNotes intervention, where patients and clinicians co-generate notes, is well received by both patients and providers, with most finding it beneficial. Patients find it easy to provide information and believe sending answers before the visit is a good idea, while clinicians typically incorporate the submissions into visit notes.

Article Computer Science, Artificial Intelligence

Fall risk assessment through a synergistic multi-source DNN learning model

Olga Andreeva, Wei Ding, Suzanne G. Leveille, Yurun Cai, Ping Chen

Summary: Falls are a major factor in the development of disabilities in older adults. This study examines novel risk factors for falls in community-living older adults and proposes a multi-source learning approach called the Synergy LSTM model, which utilizes complementarity between textual fall descriptions and people's physical characteristics.

Article Cardiac & Cardiovascular Systems

Association of Parental Cardiovascular Health With Disability-Adjusted Life Years in the Offspring: Results From the Framingham Heart Study

James M. Muchira, Philimon N. Gona, Mulubrhan F. Mogos, Eileen M. Stuart-Shor, Suzanne G. Leveille, Mariann R. Piano, Laura L. Hayman

Summary: Based on the analysis of data from the Framingham Heart Study, this research found that parental cardiovascular health is associated with cardiovascular disease burden in adult offspring. Maternal cardiovascular health was strongly associated with healthy life years lost from heart disease in offspring, while paternal cardiovascular health showed no significant association. Investment in cardiovascular health promotion could reduce the burden of cardiovascular disease in the current and future generation of adults.

Article Geriatrics & Gerontology

Self-reported symptom causes of mobility difficulty contributing to fear of falling in older adults

Michelle A. McKay, Janell L. Mensinger, Melissa O'Connor, Madison Utz, Alexander Costello, Suzanne Leveille

Summary: This study aimed to explore the self-reported symptoms causing mobility difficulties in older adults and their impact on fear of falling (FOF). The study found that pain was the primary symptom causing mobility difficulty and contributed to a higher burden of FOF.

Article Health Care Sciences & Services

Predictors of Online Patient Portal Use Among a Diverse Sample of Emerging Adults: Cross-sectional Survey

Julie A. Wright, Julie E. Volkman, Suzanne G. Leveille, Daniel J. Amante

Summary: The study found that about half of emerging adults had access to a patient portal, with the majority reporting using at least one feature. Factors associated with increased portal use included increased patient engagement and total clinical encounters. Self-reported eHealth literacy was not associated with patient portal use in this diverse sample of emerging adults.

Article Computer Science, Information Systems

Multiple Chronic Diseases Associated With Tooth Loss Among the US Adult Population

Yuqing Zhang, Suzanne G. Leveille, Ling Shi

Summary: The study found that multiple chronic diseases were associated with edentulism and tooth loss. People with multimorbidity are more likely to be edentulous than those with one or no chronic disease. The findings from this study will help to identify populations at increased risk for oral problems and nutritional deficits, thus the assessment of oral health should be evaluated further as an important component of chronic illness care.

Meeting Abstract Nursing

Symptoms Contributing to Mobility Limitations Among Older Adults Living in the Community

Michelle Mckay, Janell Mensinger, Melissa O'Connor, Madison Utz, Alexander Costello, Suzanne Leveille

Meeting Abstract Nursing

The Effect of Flexible Consumer Behaviors on Diabetes Control among Older Adults in the US

Semiha Bozkurt, Suzanne Leveille

Article Cardiac & Cardiovascular Systems

Parental cardiovascular health predicts time to onset of cardiovascular disease in offspring

James M. Muchira, Philimon N. Gona, Mulubrhan F. Mogos, Eileen Stuart-Shor, Suzanne G. Leveille, Mariann R. Piano, Laura L. Hayman

Summary: This study examined the association between parental cardiovascular health and the time to onset of cardiovascular disease in their offspring. It found that offspring of parents with ideal cardiovascular health had a greater CVD-free survival. Maternal cardiovascular health was a more accurate predictor of offspring's CVD-free survival than paternal cardiovascular health, emphasizing the importance of interventions involving mothers to break the intergenerational cycle of CVD-related morbidity and mortality.

Meeting Abstract Geriatrics & Gerontology

A REMOTE TAI CHI PROGRAM FOR DIVERSE OLDER ADULTS WITH MULTISITE PAIN DURING THE COVID-19 PANDEMIC

Yael Koren, Suzanne Leveille, Catarina Ambrizzi Moraes, William Butts, Peter Wayne, Gloria Yeh, Tongjian You